I am a Professor in Reproductive Endocrinology and Metabolism with a research line focusing on pathophysiology and molecular mechanisms of polycystic ovary syndrome (PCOS). The overarching objective of our research is to delineate the genetic versus epigenetic heritability in transmission of PCOS across generations by dissecting the molecular, mechanistic, and causal links. We know that implantation failure, miscarriage, and endometrial cancer, can be linked to endometrial dysfunction and insulin resistance and type 2 diabetes to aberrant adipose tissue function in women with PCOS. However, how cellular heterogeneity contributes to the functioning of these tissue is poorly understood. Therefore, I plan to perform single-cell analyses to reveal cell-type specific disease signatures in our unique human endometrium and adipose tissue biopsies. I will also perform bulk whole genome bisulphite sequencing (WGBS) in the same samples. We will analyze what cells interact and the impact of interaction, what is the signaling pathways involved and inter-tissue network analyses. Twenty-six scRNAseq and 26 WGBS samples of endometrium and adipose tissue respectively.