I am Associate Professor in reproductive biology and epigenetic inheritance of disease. Our research focuses on how maternal endocrinological, and metabolic dysfunction affect future offspring health by fetal programming, a process leading to a permanent change in organ structure or physiological function when exposed to unfavorable uterine environment. For this goal, we are particularly interested in polycystic ovary syndrome (PCOS), a common endocrine and metabolic syndrome affecting 10-15% of women of reproductive age. Women with PCOS suffer higher risk pregnancy complications as maternal hyperandrogenism and hyperinsulinemia impose a hostile uterine environment on fetal development. To better understand the molecular mechanisms underlying maternal-fetal interactions, we will use single-cell RNAseq and whole-genome bisulfite sequencing (WGBS) on human placentas from women with PCOS and preeclampsia in comparison with obese women and healthy controls. Since the placenta is a complex heterogeneous organ including cells of both maternal and fetal origin to provide oxygen, nutrition, and hormones, this study will provide comprehensive knowledge of cell-type composition with transcriptional and epigenetic regulation, and cellular communication networks in the placenta altered by pathological conditions. With our access to placenta biopsies from preeclampsia, PCOS women, etc by collaboration, we will gain novel insights into molecular and cellular atlas related to placenta functionality and shed insight on molecular targets for future therapeutic intervention.