Professor Tuuli Lappalainen’s research group studies functional genetic variation in the human populations. We are particularly interested in characterizing how genetic variants affect the transcriptome, and how these cellular changes contribute to genetic risk for both common and rare diseases and traits. We analyze these questions both by computational integration analysis of large genomic and transcriptomic data sets and by experimental manipulation of human cell lines. The majority of our work involves analysis of protected human data, and we thus request a SNIC SENS project to provide resources for the lab’s work.