SUPR
Single-cell RNAseq of tumor-infiltrating immune cells
Dnr:

sens2021580

Type:

SNIC SENS

Principal Investigator:

Kristina Lundberg

Affiliation:

Lunds universitet

Start Date:

2021-09-27

End Date:

2024-10-01

Primary Classification:

30110: Immunology in the medical area

Allocation

  • Castor /proj at UPPMAX: 6000 GiB
  • Cygnus /proj at UPPMAX: 6000 GiB
  • Castor /proj/nobackup at UPPMAX: 4000 GiB
  • Cygnus /proj/nobackup at UPPMAX: 4000 GiB
  • Bianca at UPPMAX: 2 x 1000 core-h/month

Abstract

The overall objective of the research is to identify and exploit novel immune cell subsets and drug targets that enables the immune system to efficiently eradicate cancer cells, and to translate those innovation into novel clinical strategies. In this particular project we perform an unbiased transcriptomic analysis using single cell RNAseq, to outline immune cell subsets and their respective transcriptomic profile, in bladder tumors. An bioinformatical pipeline to analyse single cell RNAseq data has been developed and will be employed for the analysis. The main focus of the project is T-cells and cells that regulate T-cell activity, such as myeloid cells.