The fist overall AIM is to identify factors (in this case proteins) that differ between metabolically healthy and unhealthy obesity (as well as overweight) that might explain why certain obese (or overweight individuals) develops metabolic derangements and others do not. The second overall AIM is to study which proteins that are common for the five components of the metabolic syndrome; overweight/abdominal obesity, high blood pressure, high triglycerides, low HDL, and an impaired glucose tolerance. The third overall AIM is to evaluate how different definitions of metabolically healthy and unhealthy obesity (as well as overweight), as well as different combinations of the five components of the metabolic syndrome are associated with later development of cardiovascular diseases (CVD) and mortality. The fourth overall AIM is to evaluate how proteins linked to the Metabolic syndrome and different combinations of the components are related to future CVD.