Transcriptome analysis of stem cells from the apical papilla upon exposure to oral bacteria
Dnr:
sens2021506
Type:
SNIC SENS
Principal Investigator:
Nelly Romani Vestman
Affiliation:
Umeå universitet
Start Date:
2021-01-28
End Date:
2025-06-01
Primary Classification:
30599: Other Medical and Health Sciences not elsewhere specified
Allocation
- Cygnus /proj at UPPMAX: 1000 GiB
- Cygnus /proj/nobackup at UPPMAX: 1000 GiB
- Bianca at UPPMAX: 2 x 1000 core-h/month
Abstract
The use of stem cells from the apical papilla (SCAPs) has been proposed for promoting root maturation in permanent immature teeth and has a significant role in regenerative dental procedures. However, SCAP’s role may be compromised by microenvironmental factors such as hypoxic conditions and the presence of bacteria from infected dental root canals. We aim to investigate the transcriptome profile of SCAPs from 3 donors with or without oral bacteria stimulation.