In the population-based PIVUS study, we have collected data in around 1,000 subjects all aged 70 years (50% females) on circulating levels of around 70 environmental contaminants. We also have data on multiple diseases that have evolved during 15 years of follow-up. We now AIM to study how single contaminants and mixtures of the 70 environmental contaminants are related to mortality, cardiovascular disease, dementia obesity and diabetes. We will see if the associations between contaminants and disease are mediated by epigenetic changes in DNA methylation. To study such mediation we also need genomic data, since SNPs are partly governing multiple methylation sites.