Single-cell drug reactome

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Dnr:

sens2020543

Type:

SNIC SENS

Principal Investigator:

Claes Andersson

Affiliation:

Uppsala universitet

Start Date:

2020-05-28

End Date:

2025-01-01

Primary Classification:

30102: Pharmacology and Toxicology

Webpage:

https://www.medsci.uu.se/forskning/cancerfarmakologi-och-ber-kningsmedicin/

Allocation

Cygnus /proj at UPPMAX: 2000 GiB
Cygnus /proj/nobackup at UPPMAX: 1500 GiB
Bianca at UPPMAX: 2 x 1000 core-h/month

Abstract

Transcriptional response to drug treatment is a proven valuable tool for identifying mechanism of action of compounds. This project investigates the potential of analyzing single-cell transcriptomics for mechanism/mode of action elucidation, particularly for applications in immune-oncology where co-cultures of immune and tumor cells are analyzed.