The project aims at identifying cellular and molecular signature profiles for different types of heart failure and to use this knowledge for development of biomarkers. We will analyse data from patients with HFpEF (Heart Failure with preserved Ejection Fraction) and HFrEF (Heart Failure with reduced Ejection Fraction) for genes with expression profiles in common and for genes with expression profiles distinguishing the two diseases. Myocardial biopsies from patients undergoing CABG with a) normal diastolic and systolic function, b) with reduced EF, and c) with preserved EF and diastolic dysfunction will be studied. mRNA (RNAseq) data already available will be used to study gene expression in order to define differences between the two HF conditions and define temporal changes in gene expression in HFpEF. A similar comparison will also be performed between patients with hypertension with and without HFpEF or HFrEF. The project is a scientific collaboration between Uppsala University, Karolinska Institutet and Roche.