SUPR
Immunology of granulomatous diseases
Dnr:

NAISS 2023/22-404

Type:

NAISS Small Compute

Principal Investigator:

Indranil Sinha

Affiliation:

Karolinska Institutet

Start Date:

2023-04-03

End Date:

2024-05-01

Primary Classification:

10203: Bioinformatics (Computational Biology) (applications to be 10610)

Webpage:

Allocation

Abstract

Aim: To depict the immunology of granulomatous diseases, more specifically Langerhans cell histiocytosis (LCH) and Crohn’s disease (CD), on single cell level Method: Single cell RNA seq analysis of lesions and blood Expected results: Key genes, signalling pathways and developmental trajectories of mononuclear phagocytes specific to disease development in LCH and CD.