We have a research program investigating how climate warming will impact immunocompetence in a model reptile, the Swedish sand lizard (Lacerta agilis). We will integrate population genetic and genome-wide association approaches to study the ectothermic immune response, encompassing genetic, epigenetic, transcriptional and physiological information. The aims of this research program are to determine which genes are important to immune responses in the sand lizard; test how environmental warming will impact the immune response at the epigenetic, transcriptional and physiological level and measure the standing immunogenetic diversity in natural populations of varying size and isolation to infer population-level immunocompetence. Here we are generating whole genome bisulfite sequencing of sand lizard individuals in order to investigate differential methylation patterns.