SUPR
DECLIS
Dnr:

NAISS 2023/22-313

Type:

NAISS Small Compute

Principal Investigator:

Wesley Schaal

Affiliation:

Uppsala universitet

Start Date:

2023-03-10

End Date:

2024-04-01

Primary Classification:

20404: Pharmaceutical Chemistry

Webpage:

Allocation

Abstract

Process raw data from DNA-encoded chemical libraries. Small compounds conjugated to short DNA sequences are combined in multi-step, pooled chemical reactions. The synthesized compounds are presented to a target protein. The DNA tags of the higher affinity compounds are sequenced to report the degree of enrichment. The project has been slow and as-yet unpublished but new datasets are anticipated.