The number of survivors of pediatric cancer is still increasing thanks ever evolving therapeutics, but they may be confronted with the negative lasting effects of the treatment later in life. In this project, we aim to study genomic side-effects observed in cancer survivors. Treatments are usually based on DNA-damaging chemotherapeutics and/or ionizing radiation, which actions are well understood, but any potential effects on surrounding non-cancer cells or tissues that remain post-treatment remains an open question. By sequencing patient materials pre/post treatment we will quantify and characterize any induced DNA damage and potentially aid in the long-term follow-up of these patients.