Currently i am trying to integrate about the metagenomics and metabolomics datasets from 500+ samples based on the new assigned project ID SNIC 2021/22-597. This project will have the potential to identify key bacteria and their pathways as well as metabolites that regulate the host metabolism and broaden our understanding of the importance of host-microbiota interactions in the pathogenesis and development of different metabolic diseases. In supporting the feasibility of this project, we have previously showed that the gut microbiome has shifted already in people with prediabetes long before the onset of T2D (Wu et al 2020. Cell Metabolism). Characterization of the microbially produced metabolites could help design improved diagnostic tools for T2D and even develop therapeutic options targeting on specific gut microbes and/or their metabolites.