Development of AI methods for variant interpretation, i.e. detecting which variants, typically genetic alterations, are likely disease-causing and which are benign. Methods are based on extensively selected high-quality datasets of experimentally validated cases. Storage capacity is needed for calculation of some features, especially evolutionary conservation based on ratios of synonymous and non-synonymous variations in families of orthologous sequences. These are rather heavy and space-consuming calculations. The process has to be repeated once of twice per year as new orthologues are identified.