SUPR
Single-cell RNA sequencing of germ-free lck-GFP zebrafish (Flagship).
Dnr:

SNIC 2022/23-289

Type:

SNIC Small Storage

Principal Investigator:

Bengt Fadeel

Affiliation:

Karolinska Institutet

Start Date:

2022-05-18

End Date:

2023-06-01

Primary Classification:

30110: Immunology in the medical area

Allocation

Abstract

The present work is conducted in the frame of the EU-funded Graphene Flagship project. The aim is to evaluate the impact of graphene oxide (GO) on the gut microbiome and on the immune system using zebrafish as a model. We previously performed single-cell RNA-sequencing of germ-free zebrafish embryos exposed to GO (sequencing performed at SciLifeLab). We have now performed a follow up experiment using lck-GFP transgenic fish (germ-free) in which the zebrafish were exposed to GO and cells were subsequently sorted on lck and submitted for single-cell RNA-sequencing (at SciLifeLab). We are applying for more storage space as we have already used up most of the allocated 128 GB.