Studies on antigen-specific B cells in the context of autoimmunity are scarce and hindered by the absence of a relevant antigen. Hence, the role of these cells is still debatable and the mechanism that dictates it remain to be discovered. In this project, we translate the findings in our established mouse models to the human setting and attempt to delineate antigen-specific B cells by a tetramer-based strategy. We found that these cells are present in different tissues mainly secondary lymphoid organs and their role in regulating autoimmunity is evident. Therefore, we aim to elucidate the transcription factor that control the development, proliferation and differentiation of these antigen-specific B cells.