Single-cell drug reactome
Dnr:
sens2020543
Type:
SNIC SENS
Principal Investigator:
Claes Andersson
Affiliation:
Uppsala universitet
Start Date:
2020-05-28
End Date:
2024-06-01
Primary Classification:
30102: Pharmacology and Toxicology
Allocation
- Castor /proj at UPPMAX: 2000 GiB
- Cygnus /proj at UPPMAX: 2000 GiB
- Castor /proj/nobackup at UPPMAX: 1500 GiB
- Cygnus /proj/nobackup at UPPMAX: 1500 GiB
- Bianca at UPPMAX: 2 x 1000 core-h/month
Abstract
Transcriptional response to drug treatment is a proven valuable tool for identifying mechanism of action of compounds. This project investigates the potential of analyzing single-cell transcriptomics for mechanism/mode of action elucidation, particularly for applications in immune-oncology where co-cultures of immune and tumor cells are analyzed.