Chromosomal aberrations leading to fusion genes are common somatic alterations in the cancer genome and a central question of cancer genetics. Different bioinformatic tools have been developed for discovery of gene fusions in RNA-sequencing (RNA-Seq) data. But they are focused on detection of chimeric transcripts that retain protein-coding capacity. We used a different conceptual approach to analyze to which extent genomic rearrangements that create fusion transcripts also affect genes encoded in the introns such as miRNAs (Persson et al Nat Commun 2017). The main goal is to investigate the rules that guide changes on the transcriptional control of miRNA genes encoded in introns as consequence of genomic rearrangements in cancer. We want to identify patterns enriched in specific cancer types or across cancer types and to analyze how genomic rearrangements leading to miRNA-convergent fusions are used by the cell to adapt to a new physiologic environment during carcinogenesis.